A review: continuous renal replacement therapy for sepsis-associated acute kidney injury

Sepsis is a series of systemic inflammatory reactions induced by infection and trauma, which can cause significant organ damage. Continuous renal replacement therapy (CRRT), new alternative to therapy, long-term continuous external blood purification that lasts for 24 h. This procedure remove metabolic toxins mediators in the body, as well correct water electrolyte disorders acid-base immune imbalances. article reviews clinical application CRRT treatment sepsis-associated acute kidney injury analyzes its underlying mechanisms sepsis, thereby providing theoretical basis sepsis.Highlights Hemodynamic non-hemodynamic AKI.Inflammatory oxidative stress factors mediate AKI.CRRT has therapeutic advantages prospects AKI.